The University of Southampton is one of the top 10 research-led universities in the UK and is most widely recognised for its expertise in areas such as civil engineering, physics, computer science, electrical and electronic engineering as well as mechanical, aeronautical and manufacturing engineering.

Since setting up a centre on the University of Southampton's Highfield Campus in June 2003, SETsquared has quickly established itself as a vital support to the local high-tech community. Data security, software and telecoms feature prominently among the ventures supported by SETsquared in Southampton which is co-located with the Research and Innovation Services Department (R&IS) and its associated team.

The centre in Southampton is headed up by David Bream and offers state-of-the-art incubation facilities including workstations, reception services, flexible meeting rooms, broadband connectivity and wireless LAN.